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Fluorocarbons reduce myocardial ischemic damage after coronary occlusion.

Authors: D H Glogar|||R A Kloner|||J Muller|||L W DeBoer|||E Braunwald|||L C Clark

Journal: Science (New York, N.Y.)

Publication Type: Journal Article

Date: 1981

DOI: 10.1126/science.7466402

ID: 7466402

Affiliations:

Affiliations

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Abstract

Open-chest, anesthetized dogs with occlusions of the left anterior descending coronary artery breathed 100 percent oxygen while they were bled to a hematocrit of 25 percent and infused with an approximately equal volume (40 milliliters per kilogram) of fluorocarbon preparation or Ringer solution. Dogs breathing room air and receiving no treatment served as controls. After undergoing 6 hours of coronary occlusion, animals bled and treated with fluorocarbons developed smaller infarctions than those receiving Ringer solution or no treatment.


Chemical List

    Fluorocarbons