Cardiovascular Research

Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.

Authors: K Przyklenk|||B Bauer|||M Ovize|||R A Kloner|||P Whittaker

Affiliations: + Expand

Abstract

One or more brief episodes of coronary artery occlusion protect or "precondition" the myocardium perfused by that artery from a subsequent episode of sustained ischemia. We sought to determine whether ischemic preconditioning protects only those myocytes subjected to brief coronary occlusion or whether brief occlusions in one vascular bed also limit infarct size and/or attenuate contractile dysfunction in remote virgin myocardium subjected to subsequent sustained coronary occlusion.

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Chemical List

Tetrazolium Salts|||triphenyltetrazolium