Cardiovascular Research

Previous angina alters in-hospital outcome in TIMI 4. A clinical correlate to preconditioning?

Authors: R A Kloner|||T Shook|||K Przyklenk|||V G Davis|||L Junio|||R V Matthews|||S Burstein|||M Gibson|||W K Poole|||C P Cannon

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Abstract

Ischemic preconditioning has been shown to reduce myocardial infarct size in experimental models, but its role in patients remains unclear. Angina before myocardial infarction reflects brief episodes of ischemia and may be a marker of preconditioning. As part of the Thrombolysis in Myocardial Infarction (TIMI) 4 study, we performed an analysis on the effect of a history of previous angina on in-hospital outcomes for patients with acute myocardial infarction.