Cardiovascular Research

An adenosine A1 receptor agonist, R(-)-N-(2-phenylisopropyl)-adenosine (PIA), but not adenosine itself, acts as a therapeutic pr

Authors: S L Hale|||S D Bellows|||H Hammerman|||R A Kloner

Affiliations: + Expand

Abstract

A preconditioning mimetic agent could be useful therapy for cardiac ischaemic events; stimulation of adenosine receptors has been proposed as a preconditioning mediator. The ability of adenosine-receptor activation to mimic ischaemic preconditioning was tested in an in vivo rabbit model.

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Chemical List

Receptors, Purinergic P1|||Phenylisopropyladenosine|||Adenosine