Does preconditioning protect the coronary vasculature from subsequent ischemia/reperfusion injury?
Authors:
Journal: Circulation
Publication Type: Journal Article
Date: 1993
DOI: 10.1161/01.cir.88.2.659
ID: 8339428
Abstract
"Preconditioning" with brief episodes of coronary artery occlusion reduces infarct size caused by subsequent sustained ischemia. However, the effects of preconditioning on the coronary vasculature are poorly understood. We sought to determine whether preconditioning would attenuate "low reflow" (ie, the deterioration in resting myocardial perfusion) and blunt the loss in coronary vasodilator reserve after sustained occlusion/reperfusion in the anesthetized open-chest canine model.
Chemical List
- Nitroglycerin|||Acetylcholine