Cardiovascular Research

The cardioprotective effects of ischemic 'preconditioning' are not mediated by adenosine receptors in rat hearts.

Authors: Y Li|||R A Kloner

Affiliations: + Expand

Abstract

Adenosine receptor activation has been proposed to explain the cardioprotective effect of ischemic preconditioning in rabbit hearts. We tested this hypothesis in a rat model by assessing whether administration of an adenosine antagonist could block the protective effect of preconditioning and whether adenosine is able to reduce infarct size in rat hearts when given before sustained coronary occlusion.

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Chemical List

Purinergic Antagonists|||Receptors, Purinergic|||8-(4-sulfophenyl)theophylline|||Theophylline|||Adenosine