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Direct evidence that ischemic preconditioning does not cause protein kinase C translocation in rabbit heart.

Authors: B Z Simkhovich|||K Przyklenk|||S L Hale|||M Patterson|||R A Kloner

Journal: Cardiovascular research

Publication Type: Comparative Study

Date: 1996

DOI: 10.1016/s0008-6363(96)00181-2

ID: 9015408

Affiliations:

Affiliations

    Heart Institute, Good Samaritan Hospital, Los Angeles, CA 90017, USA.||||||||||||

Abstract

Indirect pharmacological evidence suggests that myocardial protection conferred by ischemic preconditioning in rabbit myocardium is mediated through the translocation of protein kinase C (PKC). To test this hypothesis, we performed direct biochemical measurements of subcellular distribution of PKC in rabbit hearts.

Chemical List

    Protein Kinase C