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Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review.

Authors: B Z Simkhovich|||K Przyklenk|||R A Kloner

Journal: Cardiovascular research

Publication Type: Journal Article

Date: 1998

DOI: 10.1016/s0008-6363(98)00142-4

ID: 9876313

Affiliations:

Affiliations

    Heart Institute, Good Samaritan Hospital, Los Angeles, CA, USA.||||||

Abstract

Protein kinase C (PKC) has been proposed as a primary cellular mediator of ischemic preconditioning. However, the role of PKC in eliciting cardioprotection remains controversial. In this review, we summarize the evidence for and against the 'PKC hypothesis' of preconditioning, discuss the important technical limitations currently hampering PKC research, and suggest new approaches (i.e. PKC isoform-specific biochemical assays combined with immunoblotting techniques) that might aid in the definite resolution of this issue.

Chemical List

    Isoenzymes|||Protein Kinase C|||Calcium