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Resting heart rate (variability) and cognition relationships reveal cognitively healthy individuals with pathological amyloid/ta

Authors: Cathleen Molloy|||Elizabeth H Choy|||Rebecca J Arechavala|||David Buennagel|||Anne Nolty|||Mitchell R Spezzaferri|||Caleb Sin|||Shant Rising|||Jeremy Yu|||Abdulhakim Al-Ezzi|||Michael T Kleinman|||Robert A Kloner|||Xianghong Arakaki

Journal: Frontiers in epidemiology

Publication Type: Journal Article

Date: 2023

DOI: NIHMS1919996

ID: 37587981

Affiliations:

Affiliations

    Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.|||Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.|||Clinical Neuroscience Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Graduate School of Psychology & Marriage and Family Therapy, Fuller Theological Seminary, Pasadena, CA, United States.|||Department of Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, United States.|||Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Department of Environmental and Occupational Health, University of California, Irvine, Irvine, CA, United States.|||Clinical Neuroscience Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.|||Cognition and Brain Integration Laboratory, Neurosciences, Huntington Medical Research Institutes, Pasadena, CA, United States.

Abstract

Resting heart rate (HR) and heart rate variability (HRV) have been linked with cognition in the general population and in older individuals. The knowledge of this aspect of heart-brain relationship is relatively absent in older individuals with early Alzheimer's disease (AD) pathology. This study explores relationships of the HR, HRV, and cognition in cognitively healthy individuals with pathological amyloid/tau ratio (CH-PATs) in cerebral spinal fluid (CSF) compared to those with normal ratio (CH-NATs).

Reference List

    Hypertension. 2017 Apr;69(4):712-720|||Neurobiol Aging. 2017 May;53:1-10|||PLoS One. 2019 Jan 2;14(1):e0208517|||Brain Res Bull. 2002 May;58(1):61-5|||Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6106-E6115|||Sensors (Basel). 2018 Jun 03;18(6):|||Sci Rep. 2020 Jul 15;10(1):11661|||Philos Trans A Math Phys Eng Sci. 2016 May 13;374(2067):|||Hypertension. 2007 Jul;50(1):197-203|||Clin Hypertens. 2017 Jan 15;23:2|||Front Aging Neurosci. 2022 Nov 24;14:1074280|||Neurosci J. 2016;2016:6127340|||J Intern Med. 2004 Sep;256(3):183-94|||Arch Gerontol Geriatr. 2016 Mar-Apr;63:1-8|||Front Psychol. 2015 Mar 10;6:261|||Sci Rep. 2021 Jan 28;11(1):2550|||Ther Adv Chronic Dis. 2022 Feb 2;13:20406223211063020|||J Fam Psychol. 2017 Feb;31(1):41-50|||Clin Neurophysiol. 2018 Aug;129(8):1570-1578|||Psychophysiology. 2022 May;59(5):e13934|||PLoS One. 2020 Oct 19;15(10):e0240863|||N Engl J Med. 2005 May 12;352(19):1951-8|||Annu Rev Psychol. 2013;64:135-68|||Neurosci Biobehav Rev. 2012 Feb;36(2):747-56|||Med Sci Sports Exerc. 2002 Dec;34(12):1873-8|||J Neurophysiol. 2022 Sep 1;128(3):582-592|||Arch Neurol. 1992 Sep;49(9):919-22|||Biol Psychiatry. 2014 May 1;75(9):723-31|||Alzheimer Dis Assoc Disord. 2007 Jul-Sep;21(3):249-58|||Alzheimers Dement (N Y). 2019 Jul 09;5:272-293|||J Clin Hypertens (Greenwich). 2020 Apr;22(4):623-630|||Sci Rep. 2018 Feb 7;8(1):2558|||Neurobiol Aging. 2022 Apr;112:87-101|||Cardiology. 2015;132(4):199-212|||Alzheimers Dement. 2011 Jan;7(1):35-52|||Psychophysiology. 2000 Sep;37(5):607-13|||Front Neurosci. 2019 Jul 09;13:710|||Psychopharmacology (Berl). 2000 Mar;149(1):63-71|||Ann Behav Med. 2009 Apr;37(2):141-53|||J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1312-5|||Front Aging Neurosci. 2020 Oct 14;12:574214|||Nat Commun. 2018 Nov 19;9(1):4878|||Front Aging Neurosci. 2022 Sep 15;14:886023|||J Sports Med Phys Fitness. 2019 Apr;59(4):717-722|||Curr Hypertens Rev. 2012 May;8(2):80-90|||Parkinsonism Relat Disord. 2015 Jul;21(7):749-54|||Eur Heart J. 2014 Jul;35(26):1719-25|||Neurology. 1984 Jul;34(7):939-44|||Alzheimer Dis Assoc Disord. 1998 Dec;12(4):356-61|||Curr Dir Psychol Sci. 2012 Feb;21(1):8-14|||Lancet. 2008 Sep 6;372(9641):817-21|||J Am Coll Cardiol. 2007 Aug 28;50(9):823-30|||Int J Psychophysiol. 2021 Dec;170:102-111|||J Physiol. 2017 Nov 15;595(22):6969-6978|||Alzheimers Dement. 2011 May;7(3):263-9|||Neuroimage. 2019 Aug 15;197:383-390|||PLoS One. 2013 Nov 18;8(11):e79378|||Science. 2020 Mar 6;367(6482):1105-1112|||Circulation. 1979 Jul;60(1):164-9|||Am J Pharm Educ. 2008 Jun 15;72(3):60|||Psychophysiology. 2016 Dec;53(12):1843-1851|||J Am Coll Cardiol. 1997 Oct;30(4):1104-6|||J Am Coll Cardiol. 2010 Dec 7;56(24):1973-83|||Br J Pharmacol. 2008 Jun;154(4):749-57