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Obesity-related immune responses and their impact on surgical outcomes.

Authors: M Quante|||A Dietrich|||A ElKhal|||S G Tullius

Journal: International journal of obesity (2005)

Publication Type: Journal Article

Date: 2015

DOI: 10.1038/ijo.2015.21

ID: 25697667

Affiliations:

Affiliations

    1] Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] IFB Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany [3] Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.|||1] IFB Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany [2] Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.|||Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.|||Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking obesity to changes of metabolism and immune responses. This concept provides an integrated inflammatory network based on the perception of obesity as a state of chronic low-grade inflammation. With a more detailed understanding of this dynamic network and mechanistic insights, novel treatment and management strategies may be developed with the goal to optimize surgical outcomes in obese patients.

Chemical List

    Biomarkers|||Inflammation Mediators

Reference List

    World J Surg. 2013 May;37(5):1072-81|||Ann Surg. 2012 Jul;256(1):72-8|||Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):193-9|||Lancet. 2003 Jun 14;361(9374):2032-5|||Lancet. 2005 Nov 5;366(9497):1640-9|||Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14564-8|||Int J Obes (Lond). 2013 Nov;37(11):1510-3|||Nephrol Dial Transplant. 2012 Oct;27(10):3732-5|||J Vasc Surg. 2009 Jan;49(1):140-7, 147.e1; discussion 147|||Biochem Biophys Res Commun. 2004 Oct 15;323(2):630-5|||Obes Surg. 2010 Mar;20(3):383-5|||Surg Obes Relat Dis. 2013 Sep-Oct;9(5):609-16|||Nature. 1998 Aug 27;394(6696):897-901|||BMJ. 2013 Oct 22;347:f5934|||Am J Epidemiol. 1996 Feb 1;143(3):228-39|||Nat Rev Rheumatol. 2013 Nov;9(11):674-86|||Surg Obes Relat Dis. 2013 Sep-Oct;9(5):653-8|||Semin Dial. 2013 Sep-Oct;26(5):568-77|||Can J Appl Physiol. 2004 Aug;29(4):419-43|||Transpl Int. 2013 Feb;26(2):170-6|||J Gastrointest Surg. 2008 Feb;12 (2):270-8|||Am J Transplant. 2013 Jan;13(1):36-44|||Surg Clin North Am. 2013 Dec;93(6):1359-71|||Annu Rev Pathol. 2011;6:275-97|||Nephrol Dial Transplant. 2010 Oct;25(10):3142-7|||Ann Surg. 2013 Oct;258(4):628-36; discussion 636-7|||Am Surg. 2002 Feb;68(2):163-6|||Ann Surg. 2011 Mar;253(3):484-7|||Nat Immunol. 2012 Jul 19;13(8):707-12|||Nat Rev Immunol. 2006 Oct;6(10):772-83|||Immunol Rev. 2012 Sep;249(1):116-34|||Autoimmun Rev. 2010 Jun;9(8):536-9|||Am J Surg. 2000 Apr;179(4):275-81|||Clin J Am Soc Nephrol. 2011 Jun;6(6):1463-73|||Diabetes Care. 2009 Sep;32(9):1663-8|||Gastroenterology. 2007 May;132(6):2169-80|||Nature. 2006 Dec 14;444(7121):860-7|||Transplantation. 2009 Apr 27;87(8):1167-73|||J Intern Med. 2013 Mar;273(3):219-34|||Trends Endocrinol Metab. 2011 Jan;22(1):16-23|||JPEN J Parenter Enteral Nutr. 2013 Nov;37(6):714-44|||Int J Clin Pract Suppl. 2010 Feb;(166):53-8|||Ann Surg. 2004 Sep;240(3):416-23; discussion 423-4|||Ann Surg. 2013 Nov;258(5):722-30|||Transplantation. 2013 Jul 15;96(1):10-6|||J Vasc Res. 2005 Nov-Dec;42(6):517-25|||Surg Infect (Larchmt). 2009 Apr;10(2):137-42|||Ann Surg. 2014 Mar;259(3):576-81|||Diabetes. 2005 Aug;54(8):2277-86|||J Immunol. 2001 May 15;166(10):5909-16|||Nat Med. 2009 Dec;15(12):1357-8|||J Pharm Sci. 2012 May;101(5):1647-58|||Ann Surg. 2009 Jul;250(1):166-72|||J Clin Invest. 2012 Dec;122(12):4667-74|||BMJ. 2013 Aug 23;347:f5061|||Hepatogastroenterology. 2004 Jul-Aug;51(58):1225-8|||Front Endocrinol (Lausanne). 2013 Jun 10;4:69|||Ann Surg. 2013 Dec;258(6):1119-29|||Int J Obes (Lond). 2012 Aug;36(8):1072-7|||Diabetes Care. 2011 Jul;34(7):e121|||Pediatr Gastroenterol Hepatol Nutr. 2013 Sep;16(3):143-52|||Adv Exp Med Biol. 2012;942:235-47|||Transplantation. 2009 Oct 15;88(7):879-83|||World J Surg. 2007 Mar;31(3):556-60; discussion 561|||Exp Clin Endocrinol Diabetes. 2013 Aug;121(8):483-7|||J Clin Invest. 1991 Jan;87(1):262-9|||J Endourol. 2013 Feb;27(2):242-4|||Obes Surg. 2012 Jun;22(6):950-5|||J Clin Invest. 2007 Jan;117(1):175-84|||Obes Surg. 2013 Nov;23(11):1790-8|||World J Surg. 2013 Nov;37(11):2561-8|||Obes Surg. 2004 Feb;14(2):275-81|||N Engl J Med. 2014 Jan 16;370(3):233-44|||Minerva Med. 2013 Jun;104(3):309-16|||Immunol Rev. 2012 Sep;249(1):218-38|||Obes Surg. 2012 Jul;22(7):1084-96|||JAMA. 2012 Feb 1;307(5):491-7|||Ann Surg. 2013 May;257(5):978-84|||Am J Med. 2009 Mar;122(3):248-256.e5|||Nat Rev Immunol. 2011 Oct 10;11(11):738-49|||ScientificWorldJournal. 2013 Nov 07;2013:752071|||J Gastrointest Surg. 2010 Aug;14(8):1285-91|||Ann Surg Oncol. 2008 Aug;15(8):2164-72|||Biomed Res Int. 2013;2013:205467|||N Engl J Med. 2007 Apr 12;356(15):1517-26|||J Am Coll Surg. 2013 Nov;217(5):874-80.e1|||Cytokine. 2013 Nov;64(2):490-3|||Obes Surg. 2012 Jun;22(6):910-7|||J Vasc Surg. 2010 Dec;52(6):1471-7|||Obesity (Silver Spring). 2014 Jan;22(1):188-94|||Proc Nutr Soc. 2012 May;71(2):298-306|||Lancet. 2004 Nov 13-19;364(9447):1814-27|||Clin Nutr. 2008 Feb;27(1):16-24|||Obes Facts. 2013;6(2):193-202