Cardiovascular Signaling Research, Nicole H. Purcell

Increased PHLPP1 expression through ERK-4E-BP1 signaling axis drives nicotine induced oxidative stress related damage of cardiom

Authors: Khaja Shameem Mohammed Abdul|||Kimin Han|||Alyssa B Guerrero|||Cekia N Wilson|||Amogh Kulkarni|||Nicole H Purcell

Date: 2024

PMID: 38851627

On the PHLPPside: Emerging roles of PHLPP phosphatases in the heart.

Authors: Kellie A Lemoine|||Julianna M Fassas|||Shirag H Ohannesian|||Nicole H Purcell

Date: 2021

PMID: 34320369

Young@Heart: empowering the next generation of cardiovascular researchers.

Authors: M F Hoes|||A S J M Te Riele|||M M Gladka|||B D Westenbrink|||G P J van Hout|||M M G van den Hoogenhof|||A Ghigo|||S Bollini|||N H Purcell|||S M A Sohaib|||I Kardys|||D W D Kuster

Date: 2020

PMID: 32780328

PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardia

Authors: Szu-Tsen Yeh|||Cristina M Zambrano|||Walter J Koch|||Nicole H Purcell

Date: 2018

PMID: 29628444

Decline in cellular function of aged mouse c-kit cardiac progenitor cells.

Authors: Alessandra Castaldi|||Ramsinh Mansinh Dodia|||Amabel M Orogo|||Cristina M Zambrano|||Rita H Najor|||Åsa B Gustafsson|||Joan Heller Brown|||Nicole H Purcell

Date: 2017

PMID: 28737214

Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes.

Authors: Stephanie S Dusaban|||Jerold Chun|||Hugh Rosen|||Nicole H Purcell|||Joan Heller Brown

Date: 2017

PMID: 28577576

Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection.

Authors: Bryan S Yung|||Cameron S Brand|||Sunny Y Xiang|||Charles B B Gray|||Christopher K Means|||Hugh Rosen|||Jerold Chun|||Nicole H Purcell|||Joan Heller Brown|||Shigeki Miyamoto

Date: 2017

PMID: 28017639

Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs.

Authors: Alessandra Castaldi|||Gino P Chesini|||Amy E Taylor|||Mark A Sussman|||Joan Heller Brown|||Nicole H Purcell

Date: 2016

PMID: 27094722

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

Authors: KyeongJin Kim|||Li Qiang|||Matthew S Hayden|||David P Sparling|||Nicole H Purcell|||Utpal B Pajvani

Date: 2016

PMID: 26743335

Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy.

Authors: Courtney Moc|||Amy E Taylor|||Gino P Chesini|||Cristina M Zambrano|||Melissa S Barlow|||Xiaoxue Zhang|||Åsa B Gustafsson|||Nicole H Purcell

Date: 2015

PMID: 25411382

Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.

Authors: Stephanie S Dusaban|||Nicole H Purcell|||Edward Rockenstein|||Eliezer Masliah|||Min Kyung Cho|||Alan V Smrcka|||Joan Heller Brown

Date: 2013

PMID: 23401561

Ca2+/Calmodulin-dependent protein kinase II δ mediates myocardial ischemia/reperfusion injury through nuclear factor-κB.

Authors: Haiyun Ling|||Charles B B Gray|||Alexander C Zambon|||Michael Grimm|||Yusu Gu|||Nancy Dalton|||Nicole H Purcell|||Kirk Peterson|||Joan Heller Brown

Date: 2013

PMID: 23388157

PHLPP1 gene deletion protects the brain from ischemic injury.

Authors: Bo Chen|||Jessica A Van Winkle|||Patrick D Lyden|||Joan H Brown|||Nicole H Purcell

Date: 2013

PMID: 23072745

Collagen XIV is important for growth and structural integrity of the myocardium.

Authors: Ge Tao|||Agata K Levay|||Jacqueline D Peacock|||Danielle J Huk|||Sarah N Both|||Nicole H Purcell|||Jose R Pinto|||Maarten L Galantowicz|||Manuel Koch|||Pamela A Lucchesi|||David E Birk|||Joy Lincoln

Date: 2012

PMID: 22906538

APJ acts as a dual receptor in cardiac hypertrophy.

Authors: Maria Cecilia Scimia|||Cecilia Hurtado|||Saugata Ray|||Scott Metzler|||Ke Wei|||Jianming Wang|||Chris E Woods|||Nicole H Purcell|||Daniele Catalucci|||Takeshi Akasaka|||Orlando F Bueno|||George P Vlasuk|||Perla Kaliman|||Rolf Bodmer|||Layton H Smith|||Euan Ashley|||Mark Mercola|||Joan Heller Brown|||Pilar Ruiz-Lozano

Date: 2012

PMID: 22810587

RhoA protects the mouse heart against ischemia/reperfusion injury.

Authors: Sunny Yang Xiang|||Davy Vanhoutte|||Dominic P Del Re|||Nicole H Purcell|||Haiyun Ling|||Indroneal Banerjee|||Julie Bossuyt|||Richard A Lang|||Yi Zheng|||Scot J Matkovich|||Shigeki Miyamoto|||Jeffery D Molkentin|||Gerald W Dorn|||Joan Heller Brown

Date: 2011

PMID: 21747165

PHLPP-1 negatively regulates Akt activity and survival in the heart.

Authors: Shigeki Miyamoto|||Nicole H Purcell|||Jeffrey M Smith|||Tianyan Gao|||Ross Whittaker|||Katherine Huang|||Rene Castillo|||Chris C Glembotski|||Mark A Sussman|||Alexandra C Newton|||Joan Heller Brown

Date: 2010

PMID: 20576936

DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecti

Authors: Marjorie Maillet|||Nicole H Purcell|||Michelle A Sargent|||Allen J York|||Orlando F Bueno|||Jeffery D Molkentin

Date: 2008

PMID: 18753132

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in viv

Authors: Nicole H Purcell|||Benjamin J Wilkins|||Allen York|||Marc K Saba-El-Leil|||Sylvain Meloche|||Jeffrey Robbins|||Jeffery D Molkentin

Date: 2007

PMID: 17709754

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.

Authors: Christopher P Baines|||Robert A Kaiser|||Nicole H Purcell|||N Scott Blair|||Hanna Osinska|||Michael A Hambleton|||Eric W Brunskill|||M Richard Sayen|||Roberta A Gottlieb|||Gerald W Dorn|||Jeffrey Robbins|||Jeffery D Molkentin

Date: 2005

PMID: 15800627

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.

Authors: Daniel J Lips|||Orlando F Bueno|||Benjamin J Wilkins|||Nicole H Purcell|||Robert A Kaiser|||John N Lorenz|||Laure Voisin|||Marc K Saba-El-Leil|||Sylvain Meloche|||Jacques Pouysségur|||Gilles Pagès|||Leon J De Windt|||Pieter A Doevendans|||Jeffery D Molkentin

Date: 2004

PMID: 15096454

Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocyte

Authors: Nicole H Purcell|||Dina Darwis|||Orlando F Bueno|||Judith M Müller|||Roland Schüle|||Jeffery D Molkentin

Date: 2004

PMID: 14729955

Is nuclear factor kappaB an attractive therapeutic target for treating cardiac hypertrophy?

Authors: Nicole H Purcell|||Jeffery D Molkentin

Date: 2003

PMID: 12912791

Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy.

Authors: Sudhiranjan Gupta|||Nicole H Purcell|||Anning Lin|||Subha Sen

Date: 2002

PMID: 12486112

Inhibition of JNK activation through NF-kappaB target genes.

Authors: G Tang|||Y Minemoto|||B Dibling|||N H Purcell|||Z Li|||M Karin|||A Lin

Date: 2001

PMID: 11713531

Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes.

Authors: N H Purcell|||G Tang|||C Yu|||F Mercurio|||J A DiDonato|||A Lin

Date: 2001

PMID: 11381115

Activation of NF-kappaB by hepatitis B virus X protein through an IkappaB kinase-independent mechanism.

Authors: N H Purcell|||C Yu|||D He|||J Xiang|||N Paran|||J A DiDonato|||S Yamaoka|||Y Shaul|||A Lin

Date: 2001

PMID: 11254493

Cardiovascular Research